Publications by PCC-funded Researchers
Recently Chocair et al published an article in BMC Cancer on research that was funded by a Prostate Cancer Canada Pilot Grant. We’ve provided a synopsis of the results below.
This study showed that prostate tumors without PTEN, a tumor suppressor gene, were associated with a higher risk of cancer recurrence – thus, PTEN loss may indicate which tumours are aggressive. The study also showed that the loss of PTEN was associated with a decrease in androgen receptor (AR), a key protein in the progression of prostate cancer. This may have consequences on cancer response to the commonly used androgen ablation therapy. These findings will be studied in a larger group of patients to fully evaluate the impact of the results. This research is a step toward the development of personalized treatment for prostate cancer based on the molecular characteristics of the tumors.
Full article citation:
PTEN genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity
Khalil Choucair, Joshua Ejdelman, Fadi Brimo, Armen Aprikian, Simone Chevalier and Jacques Lapointe
BMC Cancer 2012, 12:543,Published: 22 November 2012
Dr. John Lewis, a PCC-funded researcher, recently published an article describing breakthroughs in prostate cancer research using nanotechnology. Here’s a snapshot of these recent advances:
Chemotherapies for prostate and other cancers can result in serious side effects. This is because the amount of drug that ends up in the tumour is usually less than 10% of the drug that accumulates in normal tissues. In an article published in the journal Nano Letters, Dr. Lewis and his collaborators describe a new technology that enables the creation of "smart" nanoparticles that seek out cancer cells while avoiding healthy tissues. Prostate Cancer Canada, through its Pilot Grant Program, is supporting Dr. Lewis's group as they use this new technology to test an exciting new "smart" nanoparticle that targets the tumour's blood supply. These nanoparticles should allow us to light up those prostate tumours that are most likely to be lethal, and to deliver chemotherapies directly to the cancer.
Discovery of Novel Integrin Ligands from Combinatorial Libraries Using a Multiplex “Beads on a Bead” Approach
Choi-Fong Cho, Giulio A. Amadei, Daniel Breadner, Leonard G. Luyt, and John D. Lewis
Nano Lett., 2012, 12 (11), pp 5957–5965