“Junk DNA” found to have huge effect on cancer cells
We know that about 40% of a man’s
risk of developing prostate cancer is genetic. But what can DNA tell us about a man’s risk of developing
advanced prostate cancer? It turns out: a tremendous amount.
Men diagnosed with prostate cancer in
later stages do have treatment options, but many will eventually stop responding to things like
hormone therapy. It has historically been difficult to identify these men and understand why they develop more aggressive forms of this cancer.
The good news is that Dr. Hansen He recently discovered promising new information that will help doctors pinpoint men who are more likely to develop aggressive forms of prostate cancer, all by decoding DNA. Dr. He’s revolutionary research will also help doctors determine whether these men require different or more immediate treatment. Awarded by Prostate Cancer Canada and proudly funded by the
Movember Foundation, this project could pave the way to better treat not just prostate cancer, but other cancers, too.
Video courtesy of UHN
Dr. He’s team discovered that what has previously been referred to as “junk DNA” actually plays a huge role in tumour growth. A single change in one letter of the “junk DNA” code led men to be at a higher risk for developing aggressive prostate cancer. PSA levels also rose much quicker after radiation or surgery.
This research clarifies how important tiny changes to DNA can be. It also highlights the importance of “junk DNA,” something we weren’t previously looking at because we simply didn’t understand its purpose.
Dr. He is offering men living with aggressive prostate cancer, who have few effective treatment options, a renewed hope that they can find a treatment unique to their genetic identity.
For more information:
Arden Bagni
Manager, Communications
Prostate Cancer Canada
416-441-2131 ext 264
arden.bagni@prostatecancer.ca