Apalutamide (Erleada®)

Common name: Apalutamide
Brand name: Erleada®

What is Apalutamide?
Apalutamide has been approved for men who have non-metastatic, castrate resistant prostate cancer (nmCRPC). This means the prostate cancer:
  • has not spread to other parts of the body and
  • no longer respond to hormone therapy/androgen deprivation therapy (ADT)

How is apalutamide administered?
Apalutamide is administered orally as a tablet.

What are possible side effects of this treatment?
Everyone responds differently to hormone therapy – some experience many side effects while others experience very few. Below are some side effects experienced by those who received apalutamide. Tell your health care team about side-effects you are experiencing so they know how best to help you manage them.
  • Fatigue
  • Diarrhea
  • Nausea or decreased appetite
  • Weight loss
  • High blood pressure
  • Underactive thyroid gland
  • Falls
  • Broken bones
  • Joint pain
  • Rash
  • Hot flashes
  • Swelling in hands, ankles, feet


Is Apalutamide covered in my province or territory?
The pan-Canadian Oncology Drug Review (pCODR) recommends funding apalutamide (Erleada®) but it is not currently covered by any provincial or territorial drug program. Please talk to your doctor to learn more about apalutamide and if it is a treatment option for you.

To read pCODRs full recommendation, please click here.

For more information on pCODR, please visit www.pcodr.ca

Last reviewed: May 2019

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